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Sousa,P.J.C.; Linard,C.F.B.M.; Azevedo-Batista,D.; Oliveira,A.C.; Coelho-de-Souza,A.N.; Leal-Cardoso,J.H.. |
Mentha x villosa Huds (Labiatae) is an aromatic herb widely used in folk medicine. Since the essential oil of the herb has many pharmacological activities, including antispasmodic effects, we determined whether the oil and its major constituent, piperitenone oxide (PO), have antinociceptive activity. The essential oil of M. x villosa (EOMV) and PO administered orally at 200 mg/kg (vehicle: 0.1% Tween 80 in water) significantly reduced the writhings induced by acetic acid from control values of 59.5 ± 3.1 s (N = 10) to 31.9 ± 2.8 s (N = 10) and 23.8 ± 3.4 s (N = 10), respectively. When administered at 100 and 200 mg/kg, EOMV reduced the paw licking time for the second phase of the formalin test from the control value of 20.6 ± 2.1 s (N = 13) to 5.3 ± 2.2 s... |
Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Mentha x villosa essential oil; Analgesia; Nociception; Anti-inflammatory effect; Piperitenone oxide. |
Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000700010 |
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PIRES,ALANA F.; MARQUES,GABRIELA F.O.; ALENCAR,NYLANE M.N. DE; MARTINS,MARIA G.Q.; SILVA,MAYARA T.L. DA; NASCIMENTO,KYRIA S. DO; CAVADA,BENILDO S.; ASSREUY,ANA MARIA S.. |
Abstract: Dalbergieae tribe lectins, possessing binding affinity for galactose and mannose, present inflammatory and nociceptive effects, while those for N-acetylglucosamine are anti-inflammatory. Since the anti-inflammatory effect of the seed lectin of L. araripensis (LAL) had been already demonstrated in mice, this effect was presently evaluated in rat models of acute inflammation. LAL (0.01-1 mg/kg) was administered by intravenous (i.v.) route in male Wistar rats 30 min before paw edema induction by dextran or carrageenan, and peritonitis by carrageenan. LAL (1 mg/kg) was incubated with N-acetylglucosamine for allowing lectin-sugar interactions before injection into animals. LAL toxicity was evaluated by the parameters: body mass, organs weight, stomach... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Anti-inflammatory effect; Dalbergieae; Lectin domain; Leguminous lectin; Loncocharpus araripensis. |
Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300706 |
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